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    When the muscle contracts too often or cannot be controlled, you get symptoms of overactive bladder, which are leakage of urine (urge urinary ), needing to urinate right away (urgency), and needing to urinate often (frequency). Tell your doctor if you have any side effects that bother you or that do not go away. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels.

    Your doctor may use a lower dose of detrol if you are taking ask your doctor or pharmacist for a list of these medicines, if you are not sure. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and approximating rates.

    C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77 of the radiolabeled dose was absorbed. . This leaflet does not take the place of talking with your doctor about your condition or your treatment.

    If you are or may be pregnant, talk to your doctor about the benefits and risks of using this medication. Therefore, detrol should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. In phase 1, multiple-dose studies in which tolterodine immediate release 4 mg (2 mg bid) was administered, serum concentrations of tolterodine and of the 5-hydroxymethyl metabolite were similar in healthy elderly volunteers (aged 64 through 80 years) and healthy young volunteers (aged less than 40 years).

    It is not known if detrol could harm your unborn baby. If you miss a dose, take it as soon as possible and continue with your regular schedule. Tolterodine was also negative in female mice treated for 2 weeks before mating and during gestation with 20 mgkgday (corresponding to auc value of about 500 ghl), neither effects on reproductive performance or fertility were seen.

    Talk to your doctor about the best way to feed your baby if you take detrol. This medication may cause or increase the risk for a certain type of abnormal heart rhythm called other medications can also increase the risk of qt prolongation when taken together with tolterodine. This study was not designed to make direct statistical comparisons between drugs or dose levels. The sums of unbound serum concentrations of tolterodine immediate release and the 5-hydroxymethyl metabolite are only 25 higher during the interaction. Patients should be informed that antimuscarinic agents such as detrol may produce the following effects blurred vision, dizziness, or drowsiness.


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    Buy Detrol 1mg 360 pills in Bath at a discount No differences in the safety profile of tolterodine were identified based on age, gender, race, Based on auc values. Therefore, detrol should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. There appeared to be a greater qtc interval increase in cyp2d6 poor metabolizers than in cyp2d6 extensive metabolizers after tolterodine treatment in this study. If you miss a dose of detrol, Each white, round, biconvex, film-coated tablet. If you are taking any of these medications, speak with your doctor or pharmacist. 1 mg. See the end of this leaflet for a complete list of ingredients before starting detrol, Thus. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. The safety and effectiveness of using this medication have not been established for children. The side effects listed below are not experienced by everyone who takes this medication. Of the 1120 patients who were treated in the four phase 3, 12-week clinical studies of detrol, 474 (42) were 65 to 91 years of age.
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    The effect of 2 mg bid and 4 mg bid of tolterodine immediate release (ir) on the qt interval was evaluated in a 4-way crossover, double-blind, placebo- and active-controlled (moxifloxacin 400 mg qd) study in healthy male (n25) and female (n23) volunteers aged 18-55 years. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. A side effect is an unwanted response to a medication when it is taken in normal doses. Tell your doctor if you have any side effects that bother you or that do not go away. Talk to your doctor about the best way to feed your baby if you take detrol.

    In male mice, a dose of 30 mgkgday did not induce any adverse effects on fertility. In comparison, the human auc value for a 2 mg dose administered twice daily is estimated at 34 ghl. An interaction between two medications does not always mean that you must stop taking one of them. Three percent of patients treated with detrol 2 mg bid reported a serious adverse event versus 4 of placebo patients. In another phase 1 study, elderly volunteers (aged 71 through 81 years) were given tolterodine immediate release 2 or 4 mg (1 or 2 mg bid).

    Each white, round, biconvex, film-coated tablet, engraved with arcs above and below the letters to, contains tolterodine l-tartrate 1 mg. The 5- hydroxymethyl metabolite is not extensively protein bound, with unbound fraction concentrations averaging 36 4. The side effects listed below are not experienced by everyone who takes this medication. Table 3 95 confidence intervals (ci) for the difference between detrol (2 mg bid) and placebo for the mean change at week 12 from baseline in study 007 table 4 95 confidence intervals (ci) for the difference between detrol (2 mg bid) and placebo for the mean change at week 12 from baseline in studies 008, 009, 010 read the patient information that comes with detrol before you start using it and each time you get a refill. Keep a list of them with you to show your doctor or pharmacist each time you get a new medicine. Patients should be informed that antimuscarinic agents such as detrol may produce the following effects blurred vision, dizziness, or drowsiness. The efficacy endpoints for study 007 (see table 3) included the change from baseline for the efficacy endpoints for studies 008, 009, and 010 (see table 4) were identical to the above endpoints with the exception that the number of incontinence episodes was per 24 hours (averaged over 7 days). Women who may become pregnant should use adequate contraception (birth control) while taking this medication. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. .

    DETROL Tablets for oral administration contain 1 or 2 mg of tolterodine tartrate. The .... patients with significantly reduced hepatic function is DETROL 1 mg twice  ...

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